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Palladium-Catalyzed Decarboxylative Ortho-Ethoxycarbonylation of O‑Methyl Ketoximes and 2‑Arylpyridines with Potassium Oxalate Monoester

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journal contribution
posted on 02.10.2015 by Zhong-Yuan Li, Guan-Wu Wang
A novel method for introducing an ester group via palladium-catalyzed ligand-directed C–H activation has been explored. The ortho-ethoxycarbonylation of O-methyl ketoximes proceeded smoothly with the nontoxic and easily handled reagent potassium oxalate monoester, affording the desired products in moderate to good yields. Furthermore, pyridine could also be employed as a directing group to obtain similar results in this transformation.

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