Palladium-Catalyzed [3 + 3] Cycloaddition of Trimethylenemethane with Azomethine Imines
journal contributionposted on 17.05.2006 by Ryo Shintani, Tamio Hayashi
Any type of content formally published in an academic journal, usually following a peer-review process.
A palladium-catalyzed [3 + 3] cycloaddition of trimethylenemethane (TMM) with azomethine imines has been developed to produce hexahydropyridazine derivatives under simple and mild conditions. The use of substituted TMM precursors highlights the difference of this system from previously reported [3 + 2] cycloaddition of TMMs under palladium catalysis. The present [3 + 3] cycloaddition reactions are also applicable to couplings with nitrones.