Palladium-Catalyzed Three-Component Reaction: A Novel Method for the Synthesis of N‑Acyl Propiolamides
journal contributionposted on 26.10.2018 by Yan He, Yingchun Wang, Xinping Liang, Bin Huang, Hengshan Wang, Ying-Ming Pan
Any type of content formally published in an academic journal, usually following a peer-review process.
Palladium-catalyzed three-component reactions between terminal alkynes, isonitriles, and sodium carboxylates have been developed. This novel and operationally simple methodology provides an alternative for the synthesis of N-acyl propiolamide derivatives under mild conditions using isonitriles as the amine source and sodium carboxylates as the oxygen and acyl source.