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Palladium-Catalyzed Hydrocarbonylative Cyclization of 1,5-Dienes

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journal contribution
posted on 06.08.2019 by Suchen Zou, Bao Gao, Yao Huang, Tianze Zhang, Hanmin Huang
A novel and atom-economic palladium-catalyzed isomerization-hydrocarbonylative cyclization reaction of 1,5-dienes to 2-alkylidenecyclopentanones has been developed, which provides a rapid and straightforward approach to 2-alkylidenecyclopentanones with high stereoselectivity. The reaction was found to proceed via alkene isomerization and selective hydrocarbonylative cyclization to generate 2-alkylidenecyclopentanones with high selectivity.