Palladium-Catalyzed Direct C–H Arylation of 3‑(Methylsulfinyl)thiophenes
journal contributionposted on 16.04.2018 by Hui Jiang, Ana Bellomo, Mengnan Zhang, Patrick J. Carroll, Brian C. Manor, Tiezheng Jia, Patrick J. Walsh
Any type of content formally published in an academic journal, usually following a peer-review process.
A palladium-catalyzed direct arylation of (3-thiophene)S(O)Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerated. A method to install two different aryl groups on 3-(methylsulfinyl)thiophenes is also introduced.