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Palladium-Catalyzed Direct C–H Arylation of 3‑(Methylsulfinyl)thiophenes

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journal contribution
posted on 16.04.2018 by Hui Jiang, Ana Bellomo, Mengnan Zhang, Patrick J. Carroll, Brian C. Manor, Tiezheng Jia, Patrick J. Walsh
A palladium-catalyzed direct arylation of (3-thiophene)­S­(O)­Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerated. A method to install two different aryl groups on 3-(methylsulfinyl)­thiophenes is also introduced.