ol8b00599_si_001.pdf (4.72 MB)

Palladium-Catalyzed Direct C–H Arylation of 3‑(Methylsulfinyl)thiophenes

Download (4.72 MB)
journal contribution
posted on 16.04.2018 by Hui Jiang, Ana Bellomo, Mengnan Zhang, Patrick J. Carroll, Brian C. Manor, Tiezheng Jia, Patrick J. Walsh
A palladium-catalyzed direct arylation of (3-thiophene)­S­(O)­Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerated. A method to install two different aryl groups on 3-(methylsulfinyl)­thiophenes is also introduced.

History

Exports