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Palladium-Catalyzed C–H Monoalkoxylation of α,β-Unsaturated Carbonyl Compounds

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journal contribution
posted on 19.05.2016 by Yasunari Monguchi, Kouki Kunishima, Tomohiro Hattori, Tohru Takahashi, Yuko Shishido, Yoshinari Sawama, Hironao Sajiki
An efficient method for the direct introduction of alkoxy groups into the β-position of alkene moieties of various α,β-unsaturated carbonyl compounds through the palladium-catalyzed C­(sp2)–H monoalkoxylation using alcohols in the presence of sodium nitrite was developed; the corresponding enol ethers were selectively synthesized with minimal generation of acetals.