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Oxidative Debenzylation of N‑Benzyl Amides and O‑Benzyl Ethers Using Alkali Metal Bromide

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journal contribution
posted on 18.07.2014, 00:00 by Katsuhiko Moriyama, Yu Nakamura, Hideo Togo
The oxidative debenzylation of N-benzyl amides and O-benzyl ethers was promoted with high efficiency by a bromo radical formed through the oxidation of bromide from alkali metal bromide under mild conditions. This reaction provided the corresponding amides from N-benzyl amides and carbonyl compounds from O-benzyl ethers in high yields.