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Optimizing the Deprotection of the Amine Protecting p-Methoxyphenyl Group in an Automated Microreactor Platform

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journal contribution
posted on 18.09.2009 by Kaspar Koch, Bram J. A. van Weerdenburg, Jorge M. M. Verkade, Pieter J. Nieuwland, Floris P. J. T. Rutjes, Jan C. M. van Hest
Three factors (temperature, stoichiometry and reaction temperature) were investigated in continuous flow microreactors in an automated fashion for optimization of the removal of the p-methoxyphenyl (PMP) protecting group, thereby consuming only minute amounts of substrate (0.2 mg/sample). The optimal reaction conditions were also applied to a larger microreactor system, in which the corresponding free amine was obtained at a preparative scale.