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One-Step Synthesis of Spiropyridines, a Novel Class of C2-Symmetric Chiral Ligands, by Cobalt(I)-Catalyzed [2 + 2 + 2] Cycloadditions between Bis-Alkynenitriles and Alkynes

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journal contribution
posted on 09.12.1999 by Jesús A. Varela, Luis Castedo, Carlos Saá
Spiropyridines, a novel series of C2-symmetric ligands, can be obtained in moderate yields by means of Co(I)-catalyzed double cocyclization between bis-alkynenitriles and alkynes. This one-step method allowed the first synthesis of the interesting 7,7‘- and 8,8‘-spyropyridines from acyclic precursors.