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One-Pot Reaction of Carboxylic Acids, Ynol Ethers, and m‑CPBA for Synthesis of α‑Carbonyloxy Esters

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journal contribution
posted on 25.07.2019 by Linwei Zeng, Hironao Sajiki, Sunliang Cui
A novel one-pot reaction of carboxylic acids, ynol ethers, and m-CPBA for the synthesis of α-carbonyloxy esters in the presence of Ag2O is described. This process provides a direct approach to α-carbonyloxy esters with the achievement of formation of three C–O bonds. The protocol is featured with readily available starting materials and broad substrate scope. Control reactions and isotope-labeling reactions were conducted to elucidate a plausible mechanism.