One-Pot Reaction of Carboxylic Acids, Ynol Ethers, and m‑CPBA for Synthesis of α‑Carbonyloxy Esters
journal contributionposted on 25.07.2019 by Linwei Zeng, Hironao Sajiki, Sunliang Cui
Any type of content formally published in an academic journal, usually following a peer-review process.
A novel one-pot reaction of carboxylic acids, ynol ethers, and m-CPBA for the synthesis of α-carbonyloxy esters in the presence of Ag2O is described. This process provides a direct approach to α-carbonyloxy esters with the achievement of formation of three C–O bonds. The protocol is featured with readily available starting materials and broad substrate scope. Control reactions and isotope-labeling reactions were conducted to elucidate a plausible mechanism.