ol015814e_si_001.pdf (92.06 kB)

One-Pot, Catalytic, Asymmetric Synthesis of Polypropionates

Download (92.06 kB)
journal contribution
posted on 10.04.2001 by Michael A. Calter, Xin Guo, Wensheng Liao
The opening of methylketene dimer, followed by aldol reactions of the resulting enolate, provides a convenient access to syn,syn-dipropionate aldol adducts of a variety of aldehydes. These aldol adducts are useful precursors in the synthesis of complex polypropionates.