One-Pot, Catalytic, Asymmetric Synthesis of Polypropionates
journal contributionposted on 10.04.2001, 00:00 by Michael A. Calter, Xin Guo, Wensheng Liao
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The opening of methylketene dimer, followed by aldol reactions of the resulting enolate, provides a convenient access to syn,syn-dipropionate aldol adducts of a variety of aldehydes. These aldol adducts are useful precursors in the synthesis of complex polypropionates.