ja062171v_si_001.pdf (2.29 MB)

Oligoresorcinols Fold into Double Helices in Water

Download (2.29 MB)
journal contribution
posted on 07.06.2006, 00:00 by Hidetoshi Goto, Hiroshi Katagiri, Yoshio Furusho, Eiji Yashima
We report the first double helices with a controlled helicity in water based on oligoresorcinols as a new, simplest water-soluble structural motif. The molecular strands of the oligoresorcinols self-assemble into double helices with the aid of aromatic interactions in water as characterized by 1H NMR and absorption spectroscopies together with the X-ray crystallographic study of the pentamer. The double helix formation is sensitive to the chain length, solvent composition, and temperature. Moreover, a bias in the screw sense of the double helices was achieved by covalently attaching chiral substituents to both ends of the molecular strands.