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Oligooxopiperazines as Nonpeptidic α-Helix Mimetics

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journal contribution
posted on 02.04.2010 by Petra Tošovská, Paramjit S. Arora
A new class of nonpeptidic α-helix mimetics derived from α-amino acids and featuring chiral backbones is described. NMR and circular dichroism spectroscopies, in combination with molecular modeling studies, provide compelling evidence that oligooxopiperazine dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an α-helix.