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Novel Use of CF3SO2Cl for the Metal-Free Electrophilic Trifluoromethylthiolation

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journal contribution
posted on 28.04.2016 by Hélène Chachignon, Mayaka Maeno, Hiroya Kondo, Norio Shibata, Dominique Cahard
The regioselective trifluoromethylthiolation of indole derivatives was achieved under reductive conditions with trifluoromethanesulfonyl chloride as the readily available source of electrophilic SCF3 and a phosphine as the reducing agent. It is a straightforward process free from any metal and also applicable for the trifluoromethylthiolation of other azaarenes, enamines, and enoxysilanes.