Novel Use of CF3SO2Cl for the Metal-Free Electrophilic Trifluoromethylthiolation
journal contributionposted on 28.04.2016 by Hélène Chachignon, Mayaka Maeno, Hiroya Kondo, Norio Shibata, Dominique Cahard
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The regioselective trifluoromethylthiolation of indole derivatives was achieved under reductive conditions with trifluoromethanesulfonyl chloride as the readily available source of electrophilic SCF3 and a phosphine as the reducing agent. It is a straightforward process free from any metal and also applicable for the trifluoromethylthiolation of other azaarenes, enamines, and enoxysilanes.