Novel Synthesis of Substituted Furo[3,2‑c]chromen-4-ones via Four-component Reaction from Substituted Nitrostyrenes, Aromatic Aldehydes, Coumarins, and Ammonium Acetate
journal contributionposted on 08.07.2013 by Zhengquan Zhou, Hui Liu, Yun Li, Juanjuan Liu, Yan Li, Jinliang Liu, Juan Yao, Cunde Wang
Any type of content formally published in an academic journal, usually following a peer-review process.
An efficient and direct synthesis of 2-arylideneamino-3-aryl-4H-furo[3,2-c]chromen-4-ones has been developed via four-component reaction from substituted nitrostyrenes, aromatic aldehydes, coumarins, and ammonium acetate under very mild conditions, which involves sequentially a Michael addition, an aza-nucleophilic addition, of the imine to the double bond, an intermolecular nucleophilic addition and a dehydration reaction. The resulting biologically intriguing structures could have broad applications in related biomedical-program structures.