New Electrophilic Addition of α-Diazoesters with Ketones for Enantioselective C–N Bond Formation
journal contributionposted on 05.10.2011 by Wei Li, Xiaohua Liu, Xiaoyu Hao, Xiaolei Hu, Yangyang Chu, Weidi Cao, Song Qin, Changwei Hu, Lili Lin, Xiaoming Feng
Any type of content formally published in an academic journal, usually following a peer-review process.
α-Diazoesters were discovered to be good electrophiles in a catalytic asymmetric α-functionalization of ketones for the first time. This reaction also provided a direct and efficient method for C–N bond formation with excellent yields (up to 98%) and enantioselectivities (up to 99% ee) under mild conditions. The application of the electrophilicity of α-diazoesters opens up a novel way to access the diversity of diazo chemistry.