New Cytotoxic Cembranes from the Sea Pen Gyrophyllum sibogae
journal contributionposted on 23.07.2004 by Fernando Reyes, Ana Ardá, Rocío Martín, Rogelio Fernández, Ana Rueda, David Montalvo, Cristina Gómez, Carlos Jiménez, Jaime Rodríguez, José M Sánchez-Puelles
Any type of content formally published in an academic journal, usually following a peer-review process.
Two new cembrane-type diterpenoids have been isolated from the 2-propanol extract of the sea pen Gyrophyllum sibogae collected in South Africa: 7,8-dihydroflabellatene A (1) and 7,8-dihydroflabellatene B (2). Their structures were determined on the basis of detailed spectroscopic analysis and by single-crystal X-ray analysis of the major metabolite 1, which showed strong in vitro cytotoxicity against a panel of 13 tumor cell lines.