NH4I‑Triggered [4 + 2] Annulation of α,β-Unsaturated Ketoxime Acetates with N‑Acetyl Enamides for the Synthesis of Pyridines
journal contributionposted on 09.06.2020 by Jindian Duan, Lei Zhang, Gaochen Xu, Heming Chen, Xiaojuan Ding, Yiyang Mao, Binsen Rong, Ning Zhu, Kai Guo
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The NH4I-triggered formal [4 + 2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides has been developed. The current protocol employs electron-rich enamides as C2 synthons and enables the efficient and straightforward construction of polysubstituted pyridines in moderate to good yields based on metal-free systems. The reaction tolerates a wide range of functional groups and represents an alternate route toward the synthesis of pyridine derivatives.