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NH4I‑Triggered [4 + 2] Annulation of α,β-Unsaturated Ketoxime Acetates with N‑Acetyl Enamides for the Synthesis of Pyridines

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journal contribution
posted on 09.06.2020 by Jindian Duan, Lei Zhang, Gaochen Xu, Heming Chen, Xiaojuan Ding, Yiyang Mao, Binsen Rong, Ning Zhu, Kai Guo
The NH4I-triggered formal [4 + 2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides has been developed. The current protocol employs electron-rich enamides as C2 synthons and enables the efficient and straightforward construction of polysubstituted pyridines in moderate to good yields based on metal-free systems. The reaction tolerates a wide range of functional groups and represents an alternate route toward the synthesis of pyridine derivatives.