Multinuclear Cu-Catalysts Based on SPINOL-PHOS in Asymmetric Conjugate Addition of Organozinc Reagents
journal contributionposted on 21.02.2016 by Kohei Endo, Daisuke Hamada, Sayuri Yakeishi, Mika Ogawa, Takanori Shibata
Any type of content formally published in an academic journal, usually following a peer-review process.
Multinuclear Cu/Zn complex-catalyzed efficient asymmetric conjugate addition of organozinc reagents to acyclic and cyclic enones has been developed in the presence of a wide variety of regioisomeric chiral diols bearing phosphorus moieties as ligands. The regioisomeric SPINOL-PHOS ligands based on a SPINOL architecture showed an unexpected inversion of stereoselectivity.