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Multicomponent Polymerization System Combining Hantzsch Reaction and Reversible Addition–Fragmentation Chain Transfer to Efficiently Synthesize Well-Defined Poly(1,4-dihydropyridine)s

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journal contribution
posted on 20.01.2015 by Qingdong Zhang, Yaling Zhang, Yuan Zhao, Bin Yang, Changkui Fu, Yen Wei, Lei Tao
A novel multicomponent system has been constructed through the combination of Hantzsch reaction and reversible addition–fragmentation chain transfer (RAFT) polymerization in a one-pot manner. Compared to traditional stepwise methods, this one-pot system exhibits much more advantages to facilely and efficiently prepare well-defined poly­(1,4-dihydropyridine)­s (poly­(1,4-DHP)­s). A series of poly­(1,4-DHP) derivatives have also been successfully prepared through this Hantzsch–RAFT system using different aldehydes as reactants, suggesting this system is a general and versatile approach to prepare well-defined functional polymers with 1,4-DHPs as side groups. Since 1,4-DHP derivatives are an important class of bioactive molecules in the pharmaceutical field, this simple method to prepare poly­(1,4-DHP)­s might have potential to prepare related functional polymers for biological and pharmaceutical applications.