Multicomponent Polymerization System Combining Hantzsch Reaction and Reversible Addition–Fragmentation Chain Transfer to Efficiently Synthesize Well-Defined Poly(1,4-dihydropyridine)s
journal contributionposted on 20.01.2015 by Qingdong Zhang, Yaling Zhang, Yuan Zhao, Bin Yang, Changkui Fu, Yen Wei, Lei Tao
Any type of content formally published in an academic journal, usually following a peer-review process.
A novel multicomponent system has been constructed through the combination of Hantzsch reaction and reversible addition–fragmentation chain transfer (RAFT) polymerization in a one-pot manner. Compared to traditional stepwise methods, this one-pot system exhibits much more advantages to facilely and efficiently prepare well-defined poly(1,4-dihydropyridine)s (poly(1,4-DHP)s). A series of poly(1,4-DHP) derivatives have also been successfully prepared through this Hantzsch–RAFT system using different aldehydes as reactants, suggesting this system is a general and versatile approach to prepare well-defined functional polymers with 1,4-DHPs as side groups. Since 1,4-DHP derivatives are an important class of bioactive molecules in the pharmaceutical field, this simple method to prepare poly(1,4-DHP)s might have potential to prepare related functional polymers for biological and pharmaceutical applications.