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Mono- versus Bidentate Ligands in Rhodium-Catalyzed Asymmetric Hydrogenation. A Comparative Rate Study

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journal contribution
posted on 21.01.2003, 00:00 by Diego Peña, Adriaan J. Minnaard, André H. M. de Vries, Johannes G. de Vries, Ben L. Feringa
Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.