Mild Method for the Selective Esterification of Carboxylic Acids Based on the Garegg−Samuelsson Reaction
journal contributionposted on 01.04.2011 by Sara P. Morcillo, Luis Álvarez de Cienfuegos, Antonio J. Mota, José Justicia, Rafael Robles
Any type of content formally published in an academic journal, usually following a peer-review process.
A mild method for the selective esterification of primary alcohols is described. The use of different phosphines, I2, and imidazole allows the selective esterification of a wide variety of acids with excellent results. The generation of a bulky phosphonium-carboxylate salt as intermediate could justify the selectivity observed in this process. Additionally, amides also can be synthesized with use of this method.