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Metal-Free TEMPO-Promoted C(sp3)–H Amination To Afford Multisubstituted Benzimidazoles

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journal contribution
posted on 16.05.2014, 00:00 by Ding Xue, Ya-Qiu Long
An efficient TEMPO–air/cat. TEMPO–O2 oxidative protocol was developed to synthesize multisubstituted or fused tetracyclic benzimidazoles via a metal-free oxidative C–N coupling between the sp3 C–H and free N–H of readily available N1-benzyl/alkyl-1,2-phenylenediamines.