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Mechanism of Metal-Free C–H Activation of Branched Aldehydes and Acylation of Alkenes Using Hypervalent Iodine Compound: A Theoretical Study

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journal contribution
posted on 18.09.2015 by Julong Jiang, Romain Ramozzi, Shin Moteki, Asuka Usui, Keiji Maruoka, Keiji Morokuma
The mechanism of the C–H activation of aldehydes and the succeeding acylation of an alkene using a hypervalent iodine reagent is investigated by theoretical calculations. In contrast to the initial proposed mechanism, the present calculations show that the hypervalent iodine is the initiator of the radical reaction. The formation of acyl radical is rate-determining, and the resulting radical acts as the chain carrier. The kinetic isotope effect (KIE) of deuterated aldehyde, as well as other experimental observations, can now be rationalized from the newly proposed mechanism.

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