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Ligand-Free Copper-Catalyzed C−S Coupling of Aryl Iodides and Thiols

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journal contribution
posted on 18.07.2008 by Elena Sperotto, Gerard P. M. van Klink, Johannes G. de Vries, Gerard van Koten
A protocol for the copper-catalyzed aryl−sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1−2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.