Ligand-Free Copper-Catalyzed C−S Coupling of Aryl Iodides and Thiols
journal contributionposted on 18.07.2008 by Elena Sperotto, Gerard P. M. van Klink, Johannes G. de Vries, Gerard van Koten
Any type of content formally published in an academic journal, usually following a peer-review process.
A protocol for the copper-catalyzed aryl−sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1−2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.