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Lewis Acid-Induced Intramolecular Friedel−Crafts Cyclization of 1,3-Bis-exocyclic Dienes. A New Route to 4a-Methyltetrahydrofluorenes

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journal contribution
posted on 16.05.2003, 00:00 by Thierry Lomberget, Emilie Bentz, Didier Bouyssi, Geneviève Balme
An efficient new method for constructing the 4a-methyltetrahydrofluorene skeleton was achieved via Friedel−Crafts intramolecular cyclization of 1,3-bis-exocyclic dienes. This strategy offers a simple and promising method for accessing complex structures.