Lehualides E−K, Cytotoxic Metabolites from the Tongan Marine Sponge Plakortis sp.
journal contributionposted on 25.04.2011 by Jacqueline M. Barber, Natelle C. H. Quek, Dora C. Leahy, John H. Miller, David S. Bellows, Peter T. Northcote
Any type of content formally published in an academic journal, usually following a peer-review process.
Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E−K (5−11), four of which incorporate various sulfur functionalities. The structures of compounds 5−11 were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds 6−9 were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild-type and a drug-sensitive mutant.