Iridium-Catalyzed Regioselective Synthesis of Trifluoromethylated Isocoumarins through Annulation of Benzoic Acids with Trifluoromethylated Alkynes
journal contributionposted on 26.03.2019 by Guangyuan Liu, Guanghua Kuang, Xingxing Zhang, Naihao Lu, Yang Fu, Yiyuan Peng, Yirong Zhou
Any type of content formally published in an academic journal, usually following a peer-review process.
An unprecedented Ir-catalyzed oxidative coupling of benzoic acids with trifluoromethylated alkynes was successfully developed to provide diverse trifluoromethylated isocoumarins in moderate to good yields. This new practical procedure was highlighted by mild reaction conditions, broad substrate scope, good regioselectivity, high efficiency, and easy operation.