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Introduction of Aryl Fluorosulfates into the Realm of Catellani Reaction Substrates

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journal contribution
posted on 12.11.2019, 14:43 by Vidmantas Bieliu̅nas, Wim M. De Borggraeve
Application of activated phenol fluorosulfates as substrates in a Pd/NBE mediated sequential alkylation-arylation, commonly known as a Catellani reaction, is presented. These substrates provide a level of complementarity to the commonly used aryl halides and, in combination with a plethora of existing Catellani reaction variations, enable even wider application of this powerful synthetic tool.