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Intramolecular Iron-Mediated Diene/Olefin Cyclocoupling:  Formation of Carbon Spirocycles

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journal contribution
posted on 22.07.2004 by Anthony J. Pearson, Xiaolong Wang, Ismet B. Dorange
A short and convenient diastereoselective synthesis of all-carbon spirocylic molecules was developed. A straightforward protocol that involves rearrangement of the diene−Fe(CO)3 complex followed by cyclization delivers the desired product. The reaction substrates were easily prepared by reaction of an appropriate nucleophile and a cyclohexadienyl-Fe(CO)3 cation.