Improved Procedure for the Synthesis of Enamine N-Oxides
journal contributionposted on 06.06.2008 by David Bernier, Alexander J. Blake, Simon Woodward
Any type of content formally published in an academic journal, usually following a peer-review process.
An improved procedure for the preparation of enamine N-oxides involving aminolysis of epoxides, chlorination, N-oxidation, and dehydrochlorination is described. Although isolated β-chloroamine N-oxides are prone to rearrangements when isolated, these side reactions can be slowed by the presence of stabilizing organic acids. The scope and limitations of this strategy are discussed.