Iminolactones from Schizophyllum commune
journal contributionposted on 22.05.2015 by Xuemei Liu, Karla Frydenvang, Huizhen Liu, Lin Zhai, Ming Chen, Carl Erik Olsen, Søren Brøgger Christensen
Any type of content formally published in an academic journal, usually following a peer-review process.
Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.