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Iminolactones from Schizophyllum commune

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journal contribution
posted on 22.05.2015 by Xuemei Liu, Karla Frydenvang, Huizhen Liu, Lin Zhai, Ming Chen, Carl Erik Olsen, Søren Brøgger Christensen
Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.