Iminium Ion Cascade Reaction in the Total Synthesis of (+)-Vincadifformine
journal contributionposted on 02.09.2011 by Ganesh Pandey, Prasanna Kumara C
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An iminium ion triggered cascade reaction is described in the total synthesis of (+)-vincadifformine by the coupling of 3,3-substituted tetrahydropyridine and indole derivative. The strategy allows simultaneous construction of two new rings, three new sigma bonds, and two new stereogenic centers in one pot with complete stereochemical control.