Hymenopsins A and B and a Macrophorin Analogue from a Fungicolous Hymenopsis sp.
journal contributionposted on 26.03.2010 by Lori E. Schmidt, Stephen T. Deyrup, Jonas Baltrusaitis, Dale C. Swenson, Donald T. Wicklow, James B. Gloer
Any type of content formally published in an academic journal, usually following a peer-review process.
Hymenopsin A (1), hymenopsin B (2), and a new macrophorin analogue, 2′,3′-epoxy-13-hydroxy-4′-oxomacrophorin A (3), have been isolated from a fungicolous isolate of Hymenopsis sp. (MYC-1703; NRRL 37638). The structures and relative configurations of these compounds were assigned on the basis of 2D NMR and MS data, and the identity of 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of 2 was proposed on the basis of CD analysis using both empirical and computational methods. Compounds 2 and 3 showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Compound 3 was also active against Aspergillus flavus and Fusarium verticillioides.