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Hydrolytic Cleavage of DNA by a Ruthenium(II) Polypyridyl Complex

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journal contribution
posted on 09.07.2007, 00:00 by Megha S. Deshpande, Anupa A. Kumbhar, Avinash S. Kumbhar
The complex [Ru(bpy)2(BPG)]Cl2 (1) containing hydrogen-bond donor (N−H atoms) and acceptor (O atoms) groups mediates hydrolytic cleavage of plasmid pBR322 DNA in an enzyme-like manner. The kinetic aspects of DNA cleavage under pseudo- and true-Michaelis−Menten conditions are detailed.