Hydrogels Formed by Multiple Peptide Ligation Reactions To Fasten Corneal Transplants
journal contributionposted on 19.07.2006 by Michel Wathier, C. Starck Johnson, Terry Kim, Mark W. Grinstaff
Any type of content formally published in an academic journal, usually following a peer-review process.
A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.