Highly Sensitive Detection of Physiological Spins in a Microfluidic Device
journal contributionposted on 11.09.2013 by Florestan C. Ziem, Nicolas S. Götz, Andrea Zappe, Steffen Steinert, Jörg Wrachtrup
Any type of content formally published in an academic journal, usually following a peer-review process.
Sensing and imaging paramagnetic species under physiological conditions is a key technology in chemical and biochemical analytics, cell biology, and medical sciences. At submicrometer length scales, nitrogen-vacancy (NV) centers in diamond offer atom-sized probes for magnetic fields. We show that spin relaxation of an ensemble NV sensor allows sensing of adsorbed and freely diffusing manganese(II) ions and adsorbed ferritin. Sensitivities approach 175 Mn ions and 10 ferritin proteins per diffraction limited spot under ambient conditions.