Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature
journal contributionposted on 30.01.2017 by Loorthuraja Rasu, Jeremy M. John, Elanna Stephenson, Riley Endean, Suneth Kalapugama, Roxanne Clément, Steven H. Bergens
Any type of content formally published in an academic journal, usually following a peer-review process.
High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.