Highly Diastereoselective Preparation of (E)-Alkenylsilanes Bearing an α-Chiral Center
journal contributionposted on 15.03.2007 by Sylvie Perrone, Paul Knochel
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The copper(I)-mediated anti-SN2‘ allylic substitution allows a highly stereoselective preparation of alkenylsilanes bearing a chiral center in the α-position with high transfer of chirality. These alkenylsilanes were converted into α,β-unsaturated ketones or into the corresponding boronic esters without loss of the chiral information.