Gold vs Rhodium Catalysis: Tuning Reactivity through Catalyst Control in the C–H Alkynylation of Isoquinolones
journal contributionposted on 17.02.2016 by Aslam C. Shaikh, Dinesh R. Shinde, Nitin T. Patil
Any type of content formally published in an academic journal, usually following a peer-review process.
A site-selective C-4/C-8 alkynylation of isoquinolones catalyzed by gold and rhodium complexes is reported. A broad range of synthetically useful functional groups (−F, −Cl, −Br, −CF3, −OMe, alkyl, etc.) were tolerated, providing an efficient and robust protocol for the synthesis either C-4- or C-8-alkynylated isoquinolones.