General, Mild, and Metal-Free Synthesis of Phenyl Selenoesters from Anhydrides and Their Use in Peptide Synthesis
journal contributionposted on 17.04.2017 by Andrea Temperini, Francesca Piazzolla, Lucio Minuti, Massimo Curini, Carlo Siciliano
Any type of content formally published in an academic journal, usually following a peer-review process.
A mild, practical, and simple procedure for phenyl selenoesters synthesis from several anhydrides and diphenyl diselenide was developed. This transition-metal-free method provides a straightforward entry to storable Fmoc-amino acid selenoesters which are effective chemoselective acylating reagents. An application to oligopeptide synthesis was illustrated.