Geminal Silicon/Zinc Reagent as an Equivalent of Difluoromethylene Bis-carbanion
journal contributionposted on 07.03.2014 by Mikhail D. Kosobokov, Vitalij V. Levin, Artem A. Zemtsov, Marina I. Struchkova, Alexander A. Korlyukov, Dmitry E. Arkhipov, Alexander D. Dilman
Any type of content formally published in an academic journal, usually following a peer-review process.
A new difluorinated reagent, [difluoro(trimethylsilyl)methyl]zinc bromide, bearing C–Zn and C–Si bonds is described. The reagent is conveniently prepared by cobalt-catalyzed halogen/zinc exchange. It can be coupled with two different C-electrophiles in a stepwise manner (with allylic halides for C–Zn bond and aldehydes for C–Si bond) affording products containing a difluoromethylene fragment.