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Four New Neuroprotective Dihydropyranocoumarins from Angelica gigas

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journal contribution
posted on 28.01.2005, 00:00 by So Young Kang, Ki Yong Lee, Sang Hyun Sung, Young Choong Kim
Four new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4‘ ‘-hydroxytigloyldecursinol (1), 4‘ ‘-hydroxydecursin (2), (2‘ ‘S,3‘ ‘S)-epoxyangeloyldecursinol (3), and (2‘ ‘R,3‘ ‘R)-epoxyangeloyldecursinol (4), respectively. All four new dihydropyranocoumarins and major coumarin derivatives of A. gigas, decursinol and decursin, exhibited signficant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells at concentrations ranging from 0.1 to 10 μM.