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Formal Total Synthesis of N-Methylmaysenine

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journal contribution
posted on 16.04.2009, 00:00 by Lin Wang, Jianxian Gong, Lujiang Deng, Zheng Xiang, Zhixing Chen, Yuefan Wang, Jiahua Chen, Zhen Yang
A novel synthetic approach for the formal total synthesis of N-methylmaysenine (1) has been developed. Key steps involve the Ti-mediated vinylogous Mukaiyama aldol reaction of chiral ketene silyl N,O-acetal with β-dithiane-substituted aldehyde, an aldol condensation, and a ring-closing metathesis reaction.