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First Enantioselective Total Synthesis of (+)‑(R)‑Pinnatolide Using an Asymmetric Domino Allylation Reaction

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journal contribution
posted on 17.08.2012 by Lutz F. Tietze, Thomas Wolfram, Julian J. Holstein, Birger Dittrich
An efficient total synthesis of (+)-(R)-Pinnatolide is described. As a key step an asymmetric multicomponent domino allylation reaction of methyl levulinate is used to form the quaternary stereogenic center in a highly selective way.