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First Crystal Structure for a Gold Carbene–Protein Adduct

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journal contribution
posted on 30.06.2016 by Giarita Ferraro, Chiara Gabbiani, Antonello Merlino
The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au­(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au­(NHC)+ fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl ligand, but retaining NHC fragment.

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