First Crystal Structure for a Gold Carbene–Protein Adduct
journal contributionposted on 30.06.2016 by Giarita Ferraro, Chiara Gabbiani, Antonello Merlino
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The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)+ fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl– ligand, but retaining NHC fragment.