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Expedient Five-Step Synthesis of SIB-1508Y from Natural Nicotine

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journal contribution
posted on 27.10.2006 by Florence F. Wagner, Daniel L. Comins
Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.

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