Enantioselective Total Synthesis of (−)-Curcuquinone via Regioselective Chromium-Mediated Benzannulation
journal contributionposted on 29.04.2005 by Ana Minatti, Karl Heinz Dötz
Any type of content formally published in an academic journal, usually following a peer-review process.
A short and efficient, high-yielding enantioselective total synthesis of the marine natural product (−)-curcuquinone 1 is reported involving a regioselective [3 + 2 + 1]-benzannulation reaction as the key step. Additionally, this strategy allows the isolation of curcuhydroquinone monomethyl ether 9 as an intermediate of the benzannulation reaction and its subsequent further protection toward diversified hydroquinones.