jo302815m_si_001.pdf (2.21 MB)

Enantioselective Synthesis of 4,5-Dihydropyrroles via Domino Ring-Opening Cyclization (DROC) of N‑Activated Aziridines with Malononitrile

Download (2.21 MB)
journal contribution
posted on 15.03.2013 by Manas K. Ghorai, Deo Prakash Tiwari
An efficient and practical strategy for the synthesis of highly functionalized racemic and non-racemic 4,5-dihydropyrroles via domino ring-opening cyclization (DROC) of activated aziridines with malononitrile in excellent yield and stereoselectivity is described. The reaction serves as a tool for the synthesis of a large variety of substituted 4,5-dihydropyrroles in enantiomerically pure forms.

History

Exports