Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy
journal contributionposted on 20.01.2017 by Vivek S. Raut, Marion Jean, Nicolas Vanthuyne, Christian Roussel, Thierry Constantieux, Cyril Bressy, Xavier Bugaut, Damien Bonne, Jean Rodriguez
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For the first time, enantiomerically enriched atropoisomeric furans have been accessed using a central-to-axial chirality conversion strategy. Hence, oxidation of the enantioenriched dihydrofuran precursors gave rise to axially chiral furans with high enantiopurities accounting from excellent conversion percentages (cp) in most cases.